In a multivariate analysis, researchers found consumption of whole grains were inversely associated with the risk of developing colorectal cancer (Int J Food Sci Nutr. 2009) (DOI:10.1080/09637480802183380). A systematic review with meta-analysis of 11 cohort studies was carried out in which 1,719,590 subjects, 25 to 76 years old, participated. The period of study varied from six to 16 years, where 7,745 persons developed colorectal cancer during the follow-up period. In the multivariate analysis, the highest quintile relative risk was 0.94, whereas that for the lowest quintile was 0.96. The location of tumors was also evaluated, with tumors in the colon demonstrating a relative risk of 0.93 and tumors in the recto a relative risk equal to 0.89.
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