Maternal intake of fructose-sweetened beverages and foods during pregnancy may result in sex-specific changes in fetal and neonatal endocrinology, according to a new study published in Endocrinology. The findings also suggest maternal fructose consumption also may affect placental development.
Researchers at the University of Aukland examined female Wistar rats that were time-mated and allocated to receive either water or a fructose solution designed to provide 20 percent of caloric intake from fructose. Only female fetuses in the fructose-fed rats had higher leptin, fructose and blood glucose levels than their control counterparts. Male and female offspring of fructose-fed rats both showed higher plasma fructose levels and were hypoinsulinemic. Researchers also found that the placenta of female fetuses in the fructose-fed rats were lighter than the female fetuses in the control group.
“There has been a marked increase in the consumption of fructose-sweetened beverages and foods, particularly among women of reproductive age," said lead author Mark Vickers PhD.
Sources:
* Newswise: Maternal Fructose Intake Impacts Female and Male Fetuses Differently
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